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GB 1886.354-2021: National Food Safety Standard - Food Additive - 3-[(4-Amino-2,2-dioxo-1H-2,1,3-benzothiadiazine-5- yl)oxy]-2,2-dimethyl-N-propyl propionamide
GB 1886.354-2021
GB
NATIONAL STANDARD OF THE
PEOPLE?€?S REPUBLIC OF CHINA
National Food Safety Standard - Food Additive -
3-[(4-Amino-2,2-dioxo-1H-2,1,3-benzothiadiazine-5-
yl)oxy]-2,2-dimethyl-N-propyl propionamide
?????????-5-???)???]-2,2-?????????-N-???????????????
ISSUED ON: SEPTEMBER 07, 2021
IMPLEMENTED ON: MARCH 07, 2022
Issued by: National Health Commission of the PRC;
State Administration for Market Regulation.
Table of Contents
1 Scope ... 3??
2 Chemical name, molecular formula, structural formula, and relative molecular
mass ... 3??
3 Technical requirements ... 4??
Appendix A Determination of content of 3-[(4-Amino-2,2-dioxo-1H-2,1,3-
benzothiadiazine-5-yl)oxy]-2,2-dimethyl-N-propyl propionamide ... 5??
National Food Safety Standard - Food Additive -
3-[(4-Amino-2,2-dioxo-1H-2,1,3-benzothiadiazine-5-
yl)oxy]-2,2-dimethyl-N-propyl propionamide
1 Scope
This Standard applies to the food additive 3-[(4-Amino-2,2-dioxo-1H-2,1,3-
benzothiadiazine-5-yl)oxy]-2,2-dimethyl-N-propyl propionamide prepared by
chemical reaction with 3-hydroxy-2,2-dimethylpropionic acid, propylamine, 2-
amino-6-fluorobenzonitrile and sulfamoyl chloride as raw materials.
2 Chemical name, molecular formula, structural
formula, and relative molecular mass
2.1 Chemical name
3-[(4-Amino-2,2-dioxo-1H-2,1,3-benzothiadiazine-5-yl)oxy]-2,2-dimethyl-N-
propyl propionamide
2.2 Molecular formula
C15H22N4O4S
2.3 Structural formula
2.4 Relative molecular mass
354.42 (according to 2018 international relative atomic mass)
Appendix A
Determination of content of 3-[(4-Amino-2,2-dioxo-1H-2,1,3-
benzothiadiazine-5-yl)oxy]-2,2-dimethyl-N-propyl propionamide
A.1 Reagents and materials
A.1.1 Formic acid: Chromatographically pure.
A.1.1.1 0.1% formic acid solution: Pipette 1.00 mL of formic acid (A.1.1) into a
1000 mL volumetric flask; add water (A.1.3) to dilute to make up to volume and
shake well.
A.1.1.2 0.5% formic acid solution: Pipette 5.00 mL of formic acid (A.1.1) into a
1000 mL volumetric flask; add water (A.1.3) to dilute to make up to volume and
shake well.
A.1.2 Acetonitrile: Chromatographically pure.
A.1.3 Water: Grade 1 water specified in GB/T 6682.
A.1.4 Reference substance of 3-[(4-Amino-2,2-dioxo-1H-2,1,3-
benzothiadiazine-5-yl)oxy]-2,2-dimethyl-N-propyl propionamide: Purity???99.0%.
A.2 Apparatus
Ultra-high performance liquid chromatograph: Equipped with diode array
detector.
A.3 Reference chromatographic conditions
A.3.1 Chromatographic column: C18 liquid chromatographic column; length is
100 mm; inner diameter is 4.6 mm; particle size is 3.5 ??m; or other equivalent
chromatographic columns.
A.3.2 Mobile phase: It consists of 0.1% formic acid solution (A.1.1.1) and
acetonitrile (A.1.2) in a volume ratio of 8:2.
A.3.3 Column temperature: 25 ??C.
A.3.4 Flow rate: 1.0 mL/min.
A.3.5 Injection volume: 1 ??L.
A.3.6 Detection wavelength: 230 nm.